an electronic nose can sniff out idiopathic pulmonary fibrosis
silvano dragonieri, donato lacedonia, incoronata caccavo, pierluigi carratu, giovanna elisiana carpagnano, teresa ranieri, maria pia foschino barbaro, onofrio resta
european respiratory journal 2019 54: pa1294; doi: 10.1183/.congress-2019.pa1294
abstract
background:the current diagnostic work-up and monitoring of idiopathic pulmonary fibrosis (ipf) is often invasive, time consuming and expensive. breath analysis by electronic nose technology has shown potential in the diagnosis of numerous respiratory diseases. in this pilot study, we investigated whether exhaled breath analysis by an electronic nose could discriminate between patients with and without ipf.
目前特发性肺纤维化(ipf)的诊断工作和监测往往是侵入性的、耗时的、昂贵的。利用电子鼻技术进行呼吸分析在许多呼吸系统疾病的诊断中显示出潜力。在这项初步研究中,我们研究了电子鼻呼气分析是否可以区分患有和不患有ipf的患者。
methods:we enrolled 10 patients with well-characterized ipf (uip and nsip patterns), 10 individuals with copd and 10 healthy controls. an electronic nose (cyranose 320) was used to analyze exhaled breath samples. raw data were processed by principal component reduction and canonical discriminant analysis.
我们收集了10例特征性ipf(uip和nsip模式)患者,10例copd患者和10例健康对照者。用电子鼻(cyranose 320)分析呼出气样本。对原始数据进行主成分归约和典型判别分析。
results: the electronic nose could adequay discriminate among breath profiles of ipf, copd and healthy controls, with a cross validated accuracy of 96.7% (p<0.01).
电子鼻能充分区分ipf、copd和健康对照组的呼吸特征,交叉验证准确率为96.7%(p<0.01)
conclusions:the exhaled breath volatile organic compounds- profile of patients with ipf can be detected by an electronic nose. this suggests that breath analysis has potential for diagnosis and/or monitoring of ipf.
ipf患者呼出气中挥发性有机物可通过电子鼻进行检测。这表明呼吸分析有可能诊断和/或监测ipf。
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